Work

TLR ligand sensing by lymph node FRCs directs intranodal lymphocyte accumulation to promote immune responses

Year: 2025

Type: article

Abstract: cells, reduced the number of lymphocytes recruited into the immune response limiting vaccine efficacy against tumors. Taken together, these observations provide further evidence for a critical role of early FRC activation in driving effective immunity, placing these non-hematopoietic cells at the center of adaptive host protection.

Source: iScience

DOI: 10.1016/j.isci.2025.113734

Authors: Antonio P. Baptista, Eelco Keuning, Reina E. Mebius

Institutions: Universidade do Porto, Ghent University, VIB-UGent Center for Inflammation Research, Amsterdam University Medical Centers, Amsterdam UMC Location Vrije Universiteit Amsterdam

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240