HBV X protein regulates cancer stemness and tumor invasiveness through SENP1 in hepatocellular carcinoma
Year: 2025
Type: article
Abstract: Background & Aims: The niche in hepatocellular carcinoma (HCC) critically influences cancer stem cell (CSC)-associated properties, including stemness, early recurrence, and poor prognoses. HBV infection acts as a niche driver for tumor progression and malignancy. While the HBV X (HBx) protein has been linked to CSC-associated properties, the underlying molecular mechanisms remain unclear. Methods: using an orthotopic xenograft model. Results: . Conclusions: HBx-induced SENP1 is critical for CSC properties. SENP1 can serve as a novel biomarker for early recurrence, metastasis, and drug resistance, particularly in HBV-related HCC. Impact and implications: settings. Findings from this research highlight that HBx-induced SENP1 is crucial for promoting CSC-associated properties in HCC. SENP1 could serve as a novel biomarker of early tumor recurrence and metastasis, especially for HBV-related HCC.
Source: JHEP Reports
Authors: Yu-Chih Wu, Yen-Chiao Huang, Yen-Chiao Huang, Yung-Che Kuo, Mai-Huong Thi Ngo, Kam-Fai Lee, Yen-Tseng Sung, Hsiao-Feng Wang, Shin-Lian Doong, Liang-Mou Kuo, Te-Sheng Chang, Yen-Hua Huang, Yen-Hua Huang
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,110
Funders: National Science and Technology Council, National Science Council, Shanghai Educational Development Foundation, Ministry of Science and Technology, Taiwan, Taipei Medical University, National Taiwan University, National Science and Technology Council, Chiayi Chang Gung Memorial Hospital, Office of Research and Development, Taipei Medical University, National Yang Ming Chiao Tung University
Awards: G1363432126, G1740752177, Hbx/Il-6/Stat3 Signaling in Oct4 Protein Stability and Cancer Stemness Properties in Hbv-Related-Hcc: the Role of Senp1 and Its Clinical Impact, G5445199938, G5696323520, G5816756415, Role of Hbx and Androgen Receptor in Regulating Senp1/Stemess-Related Properties in Hbv-Related Hcc and Its Clinical Impact, Role of HBx in IL6/IGF1R Signal-Induced Expressions of Pluripotent Transcription Factor OCT4 in Hbv-Related HCC and Its Clinical Implications
OpenAlex ID: W4414979544