Work

Agonism of PIEZO1 prevents aggravated periodontitis with traumatic occlusion via MAPK signaling pathway

Year: 2025

Type: article

Abstract: , mechanical stress and lipopolysaccharide (LPS) synergistically downregulated PIEZO1 in human periodontal ligament fibroblasts (hPDLFs), reducing osteogenic potential and elevating pro-inflammatory responses. Transcriptomics identified mitogen-activated protein kinase (MAPK) pathway inhibition as a key downstream effect. Yoda1-mediated activation restored Extracellular Signal-regulated Kinase (ERK), Jun N-terminal Kinase (JNK), and p38 phosphorylation; promoted osteogenesis; and suppressed inflammatory cytokines. Overall, TO exacerbates periodontitis by suppressing PIEZO1-MAPK signaling, and PIEZO1 activation may protect periodontal tissues from mechanical and inflammatory damage.

Source: iScience

DOI: 10.1016/j.isci.2025.113688