Year: 2025
Type: article
Abstract: Parkinson's disease is a common nervous system degenerative disease in the middle-aged and elderly. Its core characteristics include motor symptoms (bradykinesia, resting tremor, muscle rigidity, postural balance disorder) and non-motor symptoms (cognitive impairment, autonomic dysfunction, etc.), which seriously affect the quality of life and health of patients. At present, the main treatment methods of Parkinson's disease include drug therapy, surgical treatment, cell therapy, and gene therapy. This paper summarizes the research results of the last five years of research into the treatment of Parkinson's disease, including ABBV-951, optimized DBS technology, induced pluripotent stem cells, and FAM171A2, with thje aim of providing a comprehensive and effective strategy for its treatment. Through the analysis of the mechanisms and advantages of different treatment methods, it is believed that the stable administration of ABBV-951 and the precise treatment of Deep Brain Stimulation are more advantageous, and may become the main treatment methods in the future. In addition, the treatment of Parkinson's disease is constantly improving and developing towards non-invasive, precise and personalized. Utilising findings from the literature, this paper discusses the improvements in pharmacological and surgical therapies compared to traditional therapies, as well as describing the therapeutic mechanisms of two new therapies, cellular therapy and gene therapy.
Author: Haoyan Cai
Institution: Qingdao Binhai University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414981246
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