Work

Clinical Significance of Endotypes of Asian Chronic Rhinosinusitis: A Review and Expert Commentary

Year: 2025

Type: article

Abstract: Chronic rhinosinusitis (CRS) is increasingly recognized as a heterogeneous condition characterized by distinct inflammatory endotypes. In Western populations, CRS is mostly type 2 (T2) eosinophilic. In contrast, Asian cohorts show higher rates of non-T2 endotypes, posing unique challenges and limiting the applicability of Western treatment models. This expert commentary and scoping review explores endotype-driven care in CRS, synthesizes current research on Asian CRS cohorts, and examines existing gaps in our understanding, particularly in non-T2 CRS. Endotype-driven care improves treatment precision and minimizes therapeutic failure. However, most models remain largely Western-centric. Establishing Asia-specific criteria, accessible diagnostics, and therapies for non-T2 disease is essential.

Source: Sinusitis

DOI: 10.3390/sinusitis9020019

Authors: Sean Bo Jie Loh, Nevin Yi Meng Chua, Lee Fang Ang, Francesco Di Pierro, Chew Lip Ng

Institutions: National University of Singapore, Nanyang Technological University, University of Insubria, Ng Teng Fong General Hospital

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,207