Effect Of Hyperosmolar 3,5% Nacl Solution On Cerebral Edema In Patients With Traumatic Brain Injury
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: In the structure of injuries, traumatic brain injury is the most dramatic. TBI remains one of the most important public health problems. Background: To study the effect of early administration of 3,5% HSS on systemic, central hemodynamics, hemostasis, ICP, CPP, efcacy and safety in isolated traumatic brain injury in an adult population. Material and methods: The study design was a retrospective - 16 patients and prospective 20-patient, single-center, randomized open clinical trial of 36 patients treated in intensive care unit (ICU) with isolated traumatic brain injury aged 18 to 88 years with depression of consciousness (4-12 Glasgow scale score), and abnormal head computed tomography fndings on admission. Daily data during 7 days after admission to the TBI included hourly measurements of ICP, recorded noninvasively using Complexmed 1.2, and if possible, by lumbar subarachnoid puncture with manometry in 9 patients, determination of serum sodium, pulse oximetry and measurements of daily diuresis, plasma osmolarity. Results: At 20-25 minutes after thebolus of 3,5% HSS injection, the ICP decreased (stage 2) below 20 mmHg, reaching an average of 19,7 mmHg, i.e. decreasing relative to the initial data by 26,3% (p<0,05). The maximum decrease of ICP was noted at the 3rd stage of the study (after 30 minutes), where, amounting to 18, 9 ± 0.73 mmHg, it was 29,3% (p<0,05) lower than the initial values. Conclusions: NaCl HSS can be used as early as possible in patients with traumatic brain injury and high risk of developing ICH.
Authors: Temur Malik Murotov, Dostan Mirzambetov
Institution: Tashkent State Medical University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414981635
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