Year: 2025
Type: article
Study design: Case Report
Abstract: Pregnancy in women with cirrhosis is uncommon and carries substantial maternal and fetal risks, yet outcomes may improve with coordinated multidisciplinary care. We prospectively followed three pregnant women with confirmed cirrhosis between January 2023 and June 2024 in a tertiary hepatology-maternal-fetal medicine clinic. Management strategies included disease severity assessment, targeted endoscopy, beta-blockers for portal hypertension, antiviral therapy for hepatitis B, hematologic optimization, and individualized delivery planning. Two women had compensated cirrhosis without portal hypertension, and one had a history of decompensation with persistent portal hypertension. Deliveries comprised two cesarean sections, one for pathological cardiotocography and one for failed trial of labor, and one induced vaginal birth following platelet transfusion. No cases of variceal hemorrhage, hepatic encephalopathy, or maternal death occurred. All neonates were liveborn with Apgar scores of 9 at one and five minutes; one had growth restriction. At six weeks postpartum, all mothers remained clinically stable, and hepatitis B prophylaxis prevented vertical transmission. This case series highlights that multidisciplinary management enables favorable outcomes in selected cirrhotic pregnancies.
Source: Cureus
DOI: 10.7759/cureus.94189
Authors: Catherine Param Paramamanathan, Krishna Kumar, Kavitha Nagandla, Khai H Wong
Institutions: Hospital Tuanku Ja’afar, IMU University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414983123