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Inherited reactive perforating collagenosis – A rare entity

Year: 2025

Type: article

Abstract: Reactive perforating collagenosis (RPC) is a rare primary perforating dermatosis, showing distinct transepidermal elimination of modified collagen across the epidermis. This condition typically appears in two forms: Hereditary variant (rare) and acquired variant. Patients present with pruritic hyperkeratotic papules with central crusting mainly over extensor areas of extremities and hands, most likely over areas of superficial trauma with vertically oriented collagen fibers on histopathology. Here, we present a case of hereditary variant of RPC with classic histopathological findings confirmed with special stains.

Source: Cosmoderma

DOI: 10.25259/csdm_40_2025

Authors: Archi Ranka, M. V. Chethan, Richa Sharma, Rachita S. Dhurat

Institution: Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Language: English

Topic: Skin Diseases and Diabetes

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414983328

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Cites: 5

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