Year: 2025
Type: review
Abstract: Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS). This changing landscape has begun to impact how vaccinologists and immunologists approach early pre-clinical vaccine development, including decentering the antigen, with a greater focus on the role of formulation science and route of delivery. Here, we review the current state of how concepts emerging from meningeal immunity are being incorporated into modern vaccine innovation, discovery, and development. Meningeal immunity represents an emerging focus in neuroimmune interactions with implications for vaccine development. Here, the authors review how insights from meningeal immunity are being integrated into vaccine innovation, with implications for treating CNS tumors, infectious diseases, and age-related neuroinflammation.
Source: Nature Communications
Authors: Manisha Menon, Colin N. Haile, David J. Dowling
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: G3353687722, G5494131953
OpenAlex ID: W4414983339