High-intensity statin on 3-year clinical outcomes in elderly acute myocardial infarction patients underwent percutaneous coronary intervention with drug-eluting stents
Year: 2025
Type: article
Study design: Observational Study
Abstract: There is limited data on high-intensity statin for secondary prevention in elderly acute myocardial infarction (AMI) patients above 75 years. This study aimed to assess the impact of high-intensity statin on 3-year outcomes in elderly AMI patients (> 75 years) who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES). From the Korea AMI registry (KAMIR)-National Institutes of Health (NIH), 2,063 elderly patients were divided into three groups based on statin therapy at discharge: high-intensity statin group (n = 521), low/moderate-intensity statin group (n = 1,419), and no statin group (n = 123). The primary endpoint was the 3-year composite of cardiac death and recurrent myocardial infarction (MI). The high-intensity statin group had a similar primary endpoint incidence compared to the low/moderate-intensity statin group (11.5% vs. 12.5%; aHR: 1.053; 95% CI: 0.780-1.423; P = 0.739), but a significantly lower incidence compared to the no statin group (11.5% vs. 22.0%; aHR: 2.433; 95% CI: 1.377-4.298; P = 0.002). Major adverse cardiac events were lower in the high-intensity statin group compared to the no statin group but similar to the low/moderate-intensity statin group. High-intensity statin significantly reduced 3-year outcomes in elderly AMI patients after PCI compared to no statin, with similar benefits to low/moderate-intensity statin.
Source: Scientific Reports
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Seoul National University Bundang Hospital, Korea University Guro Hospital, Jeju National University, Chonbuk National University, Chonnam National University, Chungbuk National University, Chungnam National University, Keimyung University, Kyungpook National University, Pusan National University, Seoul National University, Wonkwang University, Gyeongsang National University, Kyung Hee University, Gachon University, Inje University, Korea University, Yeungnam University, Chonbuk National University Hospital, Seoul National University Hospital, Kyungpook National University Hospital, Chungnam National University Hospital, Jeju National University Hospital, Pusan National University Hospital, Samsung
OpenAlex ID: W4414994159