Work

Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: formulation and in vitro assessment in co-culture monolayers and spheroids

Year: 2025

Type: article

Abstract: Sequential treatment with vismodegib-loaded PLGA nanoparticles enhanced gemcitabine toxicity by prolonging growth inhibition and further inducing apoptosis in a 3D pancreatic spheroid model.

Source: RSC Pharmaceutics

DOI: 10.1039/d5pm00161g

Authors: Ubah Abdi, Minao Zhang, Wafa T. Al-Jamal

Institution: Queen's University Belfast

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: University of Wolverhampton, Guizhou Medical University

OpenAlex ID: W4414995181

FWCI: 0.563

Cites: 50

Cited by: 3

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