Work

Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis

Year: 2025

Type: article

Abstract: Doxycycline treats and prevents several bacterial and parasitic infections and has been proposed as a possible treatment for Trichomonas vaginalis. Nested in a trial of doxycycline postexposure prophylaxis among cisgender women in Kenya, we conducted a secondary analysis of incident T. vaginalis infections. Among 224 cisgender women randomized to doxycycline postexposure prophylaxis and 225 to standard-of-care, there were 27 T. vaginalis diagnoses in the doxycycline postexposure prophylaxis group and 29 in the standard-of-care group (RR: 0.96, 95% CI: 0.54-1.73, P = .9). Understanding doxycycline postexposure prophylaxis's impact on T. vaginalis remains an important public health question that warrants further investigation.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiaf519

Authors: Fredericka Albertina Sesay, Kevin Oware, Lauren R Violette, Deborah Donnell, Josephine B Odoyo, Victor Omollo, Felix O Mogaka, R Scott McClelland, Jennifer E Balkus, Elizabeth A Bukusi, Jared M Baeten, Jenell Stewart

Institutions: University of Washington, Kenya Medical Research Institute, Harvard University, Harvard Pilgrim Health Care, Fred Hutch Cancer Center, Public Health – Seattle & King County, University of Minnesota, Hennepin Healthcare Research Institute

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Norges Idrettshøgskole, National Institutes of Health, National Institute of Mental Health

Awards: G2892780617, PrEP and dPEP: Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis, Understanding STI and HIV prevention adherence among Kenyan women, G6348329354, G7552949564, University of Washington/Fred Hutch Center for AIDS Research

OpenAlex ID: W4414998739

FWCI:

Cites: 11

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