Work

Identifying observable medication use time in administrative databases: a tutorial using nursing home residents

Year: 2025

Type: article

Abstract: Nursing home (NH) residents are an important population for pharmacoepidemiologic research due to their prevalence of multimorbidity and polypharmacy. Medicare claims are commonly used to study medication use in this population, but medications dispensed during hospitalizations or post-acute care are unobservable due to bundled payment structures. We developed algorithms to identify NH days when medication dispensings can be observed in claims. Using a cohort of NH residents in the United States from 2013 to 2020, we linked Medicare fee-for-service (FFS) claims with Minimum Data Set clinical assessments. NH days were classified as "observable medication use time" if residents were enrolled in Medicare parts A, B, and D were not receiving post-acute care and were not hospitalized. Among 12.3 million NH residents and 2.7 billion NH days, 1.1 billion days (72.4% of Medicare-enrolled days and 39.6% of all NH days) were identified as observable medication use time. Within the first 100 days of NH admission, 27.3% of days were medication-observable, increasing to 89.4% after 100 days. On average, we identified 68% more person-time, and 51% more residents, compared to standard 100-day definitions for "long-stay" NH residents. Our algorithms enhance researchers' ability to measure medication exposure time, improving the validity of pharmacoepidemiologic studies.

Source: American Journal of Epidemiology

DOI: 10.1093/aje/kwaf227