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Generation of an induced pluripotent stem cell line from a patient with Varicose veins

Year: 2025
Type: article
Abstract: Chronic venous disease is among the most common vascular diseases globally. Varicose veins (VV), characterized by permanent dilation, elongation, and tortuosity of superficial veins, is a manifestation of chronic venous disease. Here, we generated an induced pluripotent stem cell (iPSC) line from PBMCs obtained from a patient with VV. The iPSC line exhibited typical morphology, maintained undifferentiated hPSC state markers, demonstrated a normal karyotype, and successfully differentiated into all three germ layers. This iPSC line provides a valuable platform to model VV pathogenesis and investigate the molecular mechanisms underlying venous dysfunction.
DOI: 10.1016/j.scr.2025.103850
Authors: Chikage Noishiki, Amit Manhas, Shaunak S. Adkar, Dipti Tripathi, David Wu, Safa Sadat, Lu Liu, Karim Sallam, Nicholas J. Leeper, Eri Fukaya, Nazish Sayed
Language: English
Open Access status: gold
Estimated APC paid: $2,360
Funders: American Heart Association, American Vineyard Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, City of Boston
Awards: G1185693225, G356465983, The Role of Genomic Ancestry in Mediating Breast and Prostate Cancer Therapy Cardiotoxicity (Basic Science Project), G4744788572, G5290356960, G6508370195, G7566392510, G8086952763, G9000172283, G9000287075
OpenAlex ID: W4415012552
FWCI:
Cites: 6
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