Lenvatinib-Associated Osteonecrosis Around Long-standing Mandibular Implants: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Lenvatinib is associated with adverse effects such as osteonecrosis of the jaw (ONJ) in patients undergoing treatment for malignancies.This case report presents a 56-year-old male with hepatocellular carcinoma undergoing lenvatinib therapy who presented with ONJ with significant bone destruction surrounding mandibular implants.Bone loss was extensive and thus treated with sequestrectomy and curettage.Although healing was observed initially, an additional sequestrum was observed at the 3-month follow-up.This case highlights the potential link of lenvatinib associated ONJ.Further research is required to clarify the mechanisms underlying lenvatinibinduced ONJ and to improve management strategies.
Authors: Min-Jun Kang, Chaeyeon Lee, Yongjun Cho, Hyun Woong Lee, Jong-Ki Huh, Jae-Young Kim
Language: English
Topic: Bone health and treatments
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415013299