Psychometric properties of the Vitiligo Noticeability Scale using data from a phase II randomized study of upadacitinib in adults with nonsegmental vitiligo
Year: 2025
Type: article
Abstract: The Vitiligo Noticeability Scale (VNS) is a patient-reported outcome that assesses treatment success. It was originally validated by measuring the cosmetic acceptability of a single target patch before and after treatment. We further investigated the psychometric properties of the VNS and determined if it could be used as a global measure of vitiligo noticeability by using in-trial data from a phase II randomized trial (NCT04927975) assessing upadacitinib, an oral selective Janus kinase inhibitor, in patients with nonsegmental vitiligo. We found the VNS to be a valid and reliable global measure that can differentiate between clinically distinct groups and is sensitive to change.
Source: British Journal of Dermatology
DOI: 10.1093/bjd/ljaf391
Institutions: Université Paris-Est Créteil, Centre Hospitalier Universitaire Henri-Mondor, Hôpitaux Universitaires Henri-Mondor, Epidemiology in dermatology and evaluation of therapeutics, AbbVie (United States), The Catholic University of Korea St. Vincent's Hospital, Catholic University of Korea, Henry Ford Health, Henry Ford Hospital
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,920
Funder: AbbVie
OpenAlex ID: W4415014634