Work

Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Retinitis Pigmentosa

Year: 2025

Type: article

Abstract: Purpose To perform a longitudinal analysis of peripapillary retinal nerve fiber layer (pRNFL) thickness in retinitis pigmentosa (RP) patients. Design Retrospective, longidutinal study. Subjects We enrolled patients diagnosed with RP and normal controls. Methods After the baseline visit, three additional measurements of pRNFL thickness at 1-year intervals were analyzed. Main Outcome Measures PRNFL thickness Results In total, 142 eyes were included in the study; 72 in the RP group and 70 in the control group. Global pRNFL thicknesses were 89.3 ± 38.9, 86.5 ± 35.2, 84.6 ± 31.8, and 81.6 ± 31.3 μm at baseline, 1 year, 2 years, and 3 years in the RP group (P = 0.022), and 100.9 ± 6.3, 100.8 ± 7.0, 100.0 ± 6.3, and 100.3 ± 6.9 μm in the control group (P = 0.079), respectively. The reduction rate of pRNFL thickness was -2.45 μm/y in the RP group and -0.25 μm/y in the control group. In multivariate analysis, age (estimate = -0.55, P=0.021) and RP stage (estimate = -15.42, P=0.005) were significant factors associated with changes in pRNFL thickness in RP patients. Conclusions RP patients exhibited a thinner pRNFL and a faster rate of thinning over time compared to healthy controls. In RP patients, pRNFL thinning was significantly associated with age and disease stage, possibly reflecting accelerated damage with disease progression.

Source: Ophthalmology Science

DOI: 10.1016/j.xops.2025.100966

Authors: Jae-Yun Sung, Jung-Tae Kim, Yun-Sang Roh, Min-Woo Lee

Institutions: Chungnam National University Sejong Hospital, Konyang University, Konyang University Hospital

Language: English

Topic: Retinal Development and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500