Work

Application of venovenous extracorporeal membrane oxygenation combined with continuous renal replacement therapy in a high-risk liver transplant recipient: a case report

Year: 2025

Type: article

Abstract: Introduction This report describes the novel perioperative application of VV-ECMO combined with CRRT in a high-risk liver transplant recipient with irreversible hypoxemia and multi-organ dysfunction, expanding therapeutic options for traditionally contraindicated patients. Case presentation A 27-year-old male with acute-on-chronic liver failure (chronic hepatitis B + alcoholic liver disease), hepatic encephalopathy, severe pulmonary infection, and coagulopathy developed life-threatening hypoxemia (PaO 2 60 mmHg on FiO 2 100%) during transplantation. Interventions Emergency intraoperative VV-ECMO and postoperative CRRT were initiated. Outcomes ECMO was withdrawn on postoperative day 4, the ventilator on day 11, and the patient was discharged on day 61. Follow-up showed normal liver function. Conclusion Combined VV-ECMO/CRRT provides synergistic cardiopulmonary-renal support for high-risk liver transplants, creating a critical window for graft recovery. Multidisciplinary coordination is essential for success.

Source: Frontiers in Transplantation

DOI: 10.3389/frtra.2025.1683395

Authors: Li Wen Yang, Yunli Zhang, Lijun Lu, Bin Xiong

Institution: The People's Hospital of Guangxi Zhuang Autonomous Region

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,353