Work

Application Study on the Preparation of Curcumin/PVP Coprecipitated Particles Using Coaxial Nozzle in Supercritical Antisolvent

Year: 2025

Type: article

Abstract: The supercritical antisolvent-(SAS) technique serves as an environmentally benign processing method that effectively enhances the pharmacokinetic properties of poorly water-soluble drugs. Nevertheless, the existing supercritical fluid technology and processing methodologies remain underdeveloped, presenting significant barriers to large-scale industrial implementation. To overcome these limitations, a coaxial nozzle and its associated auxiliary apparatus were engineered. Taking curcumin as the research object, using polyvinylpyrrolidone-(PVP) as the polymer carrier, and ethanol and acetone as the organic solvents, curcumin/PVP coprecipitated particles were synthesized via the SAS process. A detailed examination was conducted to evaluate the influence of key processing parametersincluding acetone/ethanol-(Ac/EtOH) volume ratio, curcumin/PVP mass ratio, temperature, pressure, and solution concentrationon the particle size and distribution of the resulting coprecipitates. The coprecipitate was characterized by various characterization methods. The findings reveal that the SAS process effectively generated amorphous curcumin/PVP coprecipitates with a submicron-scale particle diameter of 337 ± 47 nm. These findings confirm the great potential of the SAS method in the production of polymer-drug composite systems.

Source: ACS Omega

DOI: 10.1021/acsomega.5c06310

Authors: Yechen Wang, Zirui Li, Fei Li, Wang Weiqiang

Institutions: Shandong University, University of Health and Rehabilitation Sciences

Language: English

Topic: Phase Equilibria and Thermodynamics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funder: National Natural Science Foundation of China