Shift from Streptococcus pneumoniae to Klebsiella pneumoniae: a 15-year nationwide study of bacterial meningitis in Korea
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Bacterial meningitis is a medical emergency with high mortality and neurologic sequelae. Its epidemiology is changing with vaccination and evolving pathogens. We investigated current etiologic patterns of adult community-acquired bacterial meningitis in Korea and outcome determinants. METHODS: In this 15-year (2009-2023) retrospective study of 17 hospitals, 247 cases were analyzed for causative organisms, and 224 for 30-day outcomes. Risk factors for mortality and neurologic sequelae were determined. RESULTS: Streptococcus pneumoniae declined from 36.4% in 2009-2013 to 19.4% in 2019-2023 (P = 0.060). Meanwhile, Klebsiella pneumoniae increased significantly (6.8% to 29.2%; P = 0.001), becoming the most common cause. K. pneumoniae meningitis showed a tendency toward higher attributable mortality (35.7%) at 30 days compared to S. pneumoniae (19.7%). Independent predictors of 30-day mortality were older age, seizure at presentation, and septic shock, whereas hypertension was associated with a lower mortality risk. Neurologic sequelae occurred in 29% and were associated with pre-existing cerebrovascular disease, headache, and stuporous consciousness. CONCLUSIONS: Over 15 years in Korea, the declining incidence of S. pneumoniae meningitis coincided with widespread pneumococcal vaccination, while K. pneumoniae has become the leading cause. Given its association with poor outcomes, K. pneumoniae meningitis requires increased awareness.
Institutions: Samsung Medical Center, Sungkyunkwan University, Hallym University, Hallym University Chuncheon Sacred Heart Hospital, Chonnam National University, Chonnam National University Hospital, Jeju National University, Inje University Busan Paik Hospital, Kyungpook National University, Kangbuk Samsung Hospital, Pusan National University Yangsan Hospital, Soonchunhyang University, Soonchunhyang University Hospital Seoul, Samsung Changwon Hospital, Keimyung University Dongsan Hospital, Keimyung University, Kyung Hee University, Chonnam National University Hwasun Hospital, Kyung Hee University Hospital at Gangdong, Kangdong Sacred Heart Hospital, Chungnam National University, Chungnam National University Hospital
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,900
OpenAlex ID: W4415020112