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Case Report: Cerebrospinal fluid eosinophilia in adult autoimmune GFAP astrocytopathy

Year: 2025

Type: article

Abstract: A 30-year-old Chinese male diagnosed with autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy presented with cerebrospinal fluid (CSF) eosinophilia. Magnetic resonance imaging (MRI) revealed no significant abnormalities; however, CSF analysis demonstrated the presence of GFAP-immunoglobulin G (IgG) antibodies. Notably, the CSF showed marked eosinophilia, which declined following methylprednisolone therapy and was accompanied by clinical improvement. The proportion of eosinophils in the CSF of this patient exceeded previously reported levels in cases of autoimmune GFAP astrocytopathy. These findings suggest a potential relationship between eosinophil infiltration and the pathogenesis of autoimmune GFAP astrocytopathy, indicating that eosinophils may contribute to disease progression.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2025.1659720

Authors: Yuting Hou, Chunmei Zhao, Xu Wang

Institutions: Ningxia Medical University, Ningxia Medical University General Hospital

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801