Work

Evaluation of serum hmgb-1 and serum p-glycoprotein levels in epileptic patients: associations with clinical features, seizure patterns, and drug resistance

Year: 2025

Type: article

Abstract: This study aimed to evaluate the association of serum HMGB-1 and serum P-gp levels with clinical characteristics, seizure patterns, and drug resistance in patients with epilepsy.Patients were divided into monotherapy (n=40) and polytherapy (n=40) groups, and their serum HMGB-1 and serum P-gp levels were analysed using the ELISA technique.In the multinomial logistic regression model, serum P-gp levels were significantly higher in the polytherapy group compared to the healthy control group (p=0.021).Additionally, to the best of our knowledge, this is the first study to analyse the correlation between serum HMGB-1 and serum P-gp levels.In this study, a moderate positive correlation

Source: ACTA Pharmaceutica Sciencia

DOI: 10.23893/1307-2080.aps6348