Work

Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles

Year: 2025

Type: article

Abstract: Ischemic heart disease (IHD) is a leading cause of mortality worldwide, primarily driven by coronary artery stenosis. Current therapies predominantly slow disease progression, with limited capacity to restore functional myocardium. Worsening metabolic disorders significantly drives heart failure. Emerging evidence suggests that stem cell therapy may improve cardiac metabolism. This review examines metabolic dysregulation in IHD and explores how stem cells and extracellular vesicles could modulate these pathways to support tissue repair.

Source: npj Cardiovascular Health

DOI: 10.1038/s44325-025-00089-z