Work

Antioxidant Power of Vitexin and Isovitexin Against OOH Radicals: A Comparative Theoretical Investigation

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The antioxidant activity of vitexin and isovitexin─flavonoids widely found in various plants and used in traditional medicine─has been theoretically evaluated against the OOH radical. Multiple reaction mechanisms, including hydrogen atom transfer, single electron transfer, and radical adduct formation, were considered. The study accounts for all species present in aqueous solution at physiological pH as well as in lipid-like environments. Both compounds exhibit similar antioxidant activities, with apparent rate constants of 1.45 × 10 3 M – 1 s – 1 for vitexin and 4.78 × 10 3 M – 1 s – 1 for isovitexin. Compared to Trolox, a commonly used reference compound, their radical scavenging capacities are slightly lower.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01680

Authors: Maciej Spiegel, Nino Russo

Institutions: Wroclaw Medical University, University of Calabria

Language: English

Topic: Free Radicals and Antioxidants

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego UW