Year: 2025
Type: article
Study design: Observational Study
Abstract: The BREAst screening Tailored for HEr (BREATHE) study was established to pilot a personalised, risk-based breast cancer screening programme for a multi-ethnic Asian population. Between October 2021 and December 2023, 4592 women aged 35-59 were enrolled (73% response rate). Follow-up from February 2022 to June 2024 included 4112 participants (8.6% loss to follow-up). Data collected encompassed demographics, lifestyle factors, reproductive risks, breast cancer awareness, screening behaviours, programme satisfaction, mammography outcomes (density and recall status), and genotype data. Above-average breast cancer risk increased with age: 2% in women aged 35-39, 31% in 40-49, and 42% in 50-59. Findings suggests that women valued the knowledge of their breast cancer risk and were motivated to attend mammography. The BREATHE study confirms the feasibility and acceptability of a personalised risk-based screening programme in a multi-ethnic Asian population, highlighting the value of tailored protocols to improve early detection and outcomes. Further details are available in the study protocol and online at https://blog.nus.edu.sg/breathe/ .
Source: Scientific Reports
Authors: Peh Joo Ho, Jenny Liu, Su-Ann Goh, Alexis Jiaying Khng, Nur Khaliesah Mohamed Riza, Ying Jia Chew, Desmond Luan Seng Ong, Yi Wang, Fook Ming Hew, Pooja Jagmohan, Premilla Gopinathan Pillay, Yonggeng Goh, Han Yang Ong, Abrar Mohammed Alsunbul, Han Boon Oh, Christopher Hang Liang Keh, Chi Hui Chin, Sing Cheer Kwek, Zhi Peng Zhang, Swee Tian Quek, Sujith Wijerathne, Jingmei Li, Philip Choong Tsau Iau, Mikael Hartman
Institutions: Agency for Science, Technology and Research, National University of Singapore, National University Health System, Genome Institute of Singapore, Ng Teng Fong General Hospital, National University Hospital, National University Polyclinics, SingHealth, Alexandra Hospital, National Cancer Centre Singapore
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4415024717