Work

ProPE expands the prime editing window and enhances gene editing efficiency where prime editing is inefficient

Year: 2025

Type: article

Abstract: Prime editing is a CRISPR methodology whose efficiency declines with distance from the target sequence. Here the authors demonstrate prime editing with prolonged editing window, proPE, which extends the editing distance, enabling the use of prime editing for therapeutic interventions.

Source: Nature Catalysis

DOI: 10.1038/s41929-025-01406-6

Authors: Sarah Laura Krausz, Dorottya Anna Simon, Zsuzsa Bartos, Zsuzsanna Biczók, Éva Varga, Krisztina Huszár, Péter István Kulcsár, András Tálas, Zoltán Ligeti, Ervin Welker

Institutions: Semmelweis University, Institute of Molecular Life Sciences, Hungarian Research Network, HUN-REN Research Centre for Natural Sciences, University of Szeged, HUN-REN Szegedi Biológiai Kutatóközpont, Institute of Biochemistry, Eötvös Loránd University

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W4415024788

FWCI: 1.768

Cites: 69

Cited by: 7

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