Year: 2025
Type: article
Abstract: The impact of chronic alcohol consumption is evident in disruptions within prefrontal circuitries, resulting in cognitive deficits that underlie lost control over drinking. Given the limited efficacy of current pharmacotherapy, we employed multifunctional bioelectronics to investigate the potential of direct electrical brain stimulation to rectify neural impairments in alcohol-dependent rats. Cortical stimulation counteracted the observed deficiencies in event-related brain potentials and neural oscillations following chronic alcohol consumption, particularly by strengthening low-beta oscillations related to executive control. Stimulation efficacy thereby correlated with individual drinking patterns. In alcohol-dependent rats, stimulation-related neuroenhancement was spatially confined to the stimulation site, indicating reduced neural connectivity, as confirmed by a computational approach to directed functional connectivity patterns. Such state-dependent factors may contribute to the varying efficacy of brain stimulation observed in patients, ultimately suggesting the need for personalized neuromodulation designs.
Source: Scientific Reports
Institutions: Leibniz Institute of Polymer Research, Technische Universität Dresden, Biotechnologisches Zentrum, Center for Molecular and Cellular Bioengineering, Center for Regenerative Therapies Dresden, Heidelberg University, Central Institute of Mental Health, Medizinische Fakultät Mannheim, Deutsches Zentrum für Psychische Gesundheit, Else Kröner Fresenius Center for Digital Health
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: DZKJ Aufbauförderung - Standort Leipzig/Dresden - SaxoChiLD TUD, Neuronale Implantattechnologie zur epikortikalen, multimodalen Modulation des Suchtverhaltens bei Abhängigkeit, AhEAD - Präklinische konfirmatorische Studie zum Einsatz von Exosomen in der Behandlung von Alkoholsucht, Studienteil am Zentralinstitut für Seelische Gesundheit Mannheim, Projektkoordination, G3434867832, G3762292575, G3986097662, G413301144
OpenAlex ID: W4415025998