Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Transvenous lead extraction (TLE) is associated with mechanical stress on the heart structures, which may be associated with an increase in cardiac troponin T (c-TnT). AIMS: The aim was to investigate whether TLE is associated with c-TnT release, and to assess its rate, magnitude, and clinical importance. MATERIAL AND METHODS: In the study, c-TnT were determined before, and at 2 and 8 hours after TLE in 166 consecutive patients. RESULTS: Initially, an elevated level of c-TnT >14 ng/l was detected in 57.32% patients, then at 2 hours in 96.99%, and at 8 hours in 98.19% (164 [98.80%] patients). After TLE c-TnT levels increased significantly from (median 17.0; interquartile range 9.00-30.00) ng/l to 66.50 (36.00-153.0) ng/l at 2 hours and to 81.5 (45.00-179.0) ng/l at 8 hours after the procedure (P <0.001). The increase was due to a greater procedure complexity, and contrary to the initial level it had no impact on one-year survival (87.95% vs. 89.16%; P = 0.81). The one-year mortality rate in patients with c-TnT(0) levels >14 ng/l was higher than in those with c-TnT(0) ≤14 ng/l (16 [17.02%] vs. 3 [4.17%]; P = 0.01, respectively) CONCLUSIONS: Elevated levels of c-TnT(0) is an unfavorable prognostic indicator. Levels of c-TnT at 2 and 8 hours after the TLE procedure were elevated in most patients. Delta c-TnT(2) and c-TnT(8) were related only to the complexity of the procedure. TLE had some effect on the heart, causing troponin release, which may complicate the diagnosis of coronary syndromes in the first days after transvenous lead extraction.
Source: Kardiologia Polska
Institutions: Medical University of Silesia, Jan Kochanowski University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415028069