Year: 2025
Type: article
Abstract: Influenza infection is a multistage process that involves the trafficking of viral particles across the cell membrane. Before endocytosis, virions target the membrane by binding hemagglutinin ligands to sialic acid residues on cell receptors. After budding, neuraminidase cleaves these residues, enabling virions to detach from the infected cell surface. In this paper, we examine detachment dynamics through simulations and theoretical analysis. We explain experimental findings showing that the time required for virions to detach can decrease as the single-trajectory average number of bonds increases─a counterintuitive result specific to neuraminidase activity. Furthermore, we demonstrate that the detachment time is not governed by a Poisson distribution but depends on multiple factors, including ligand-receptor reaction rates, virion size, and receptor diffusion constant. These results clarify how biochemical parameters regulate the residence time of virions at the cell surface.
Source: Nano Letters
Institution: Université Libre de Bruxelles
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G1163097982
OpenAlex ID: W4415031444