Year: 2024
Type: preprint
Abstract: The three RAS genes ( HRAS , KRAS , and NRAS ) comprise the most frequently mutated oncogene family in cancer. KRAS is the predominant isoform mutated in cancer and is most prevalently mutated in major causes of cancer deaths including lung, colorectal, and pancreatic cancers. Despite extensive academic and industry efforts to target KRAS, it would take nearly four decades before approval of the first clinically effective KRAS inhibitors for the treatment of KRAS mutant lung cancer. We revisit past anti-KRAS strategies and painful lessons learned and then focus on the rapidly evolving landscape of direct RAS inhibitors, resistance mechanisms, and potential combination treatments.
Source: Genes & Development
Authors: Adrienne D. Cox, Channing J. Der
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Awards: G1047483779, G1319661684, G181913650, G2221353213, Biological Activity of Ras Oncogenes, Targeting undruggable RAS for cancer treatment, Washington University SPORE in Pancreatic Cancer, G5028106406, Identification of synthetic lethal interactors in pancreatic cancer, TARGETING KRAS-DYSREGULATED METABOLISM FOR NOVEL THERAPEUTIC APPROACHES
OpenAlex ID: W4415037790