Work

Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025

Year: 2025

Type: article

Abstract: We report four confirmed autochthonously transmitted gonorrhoea cases in Germany in 2025, with Neisseria gonorrhoeae isolates exhibiting high-level azithromycin and cefixime resistance. Regarding ceftriaxone, isolates were susceptible for two cases and resistant for two, rendering the later extensively drug-resistant (XDR-NG). Cases, all heterosexual males, were in their late teens to mid-60s. Three isolates were MLST ST18091, with the mosaic penA -60.001 allele and the 23S rRNA A2045G mutation and were related to an XDR-NG detected in the United Kingdom in 2024.

Source: Eurosurveillance

DOI: 10.2807/1560-7917.es.2025.30.40.2500738

Authors: Regina Selb, Hana Tlapák, Kathleen Klaper, Susanne Buder, Klaus Jansen, Dagmar Heuer

Institution: Robert Koch Institute

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Robert Koch Institut