Work

Synthesis of nano-ZIF-90 from zinc sulfate heptahydrate and evaluation of its stability for use as a cancer drug carrier

Year: 2025

Type: article

Abstract: The paper presents the first research results on the synthesis of nano-ZIF-90 from zinc sulfate heptahydrate at room temperature. The factors of solvent composition, crystallization time and repeatability of the synthesis process of nano-ZIF-90 from ZnSO4.7H2O have been reported. The stability of synthesized nano-ZIF-90 according to temperature and environmental pH to be used as a drug carrier for cancer treatment is also discussed. XRD, F-TIR, SEM, TEM, BET and DTA/TGA methods have been used to characterize the structure and properties of the studied samples. The synthesized nano-ZIF-90 material has crystallinity of 100 % (by XRD), specific surface area of 468 m2/g (by BET), crystal size of 43 nm (by TEM), and thermal stability up to 250 oC. In particular, it was determined that at pH = 5.5, the nano-ZIF-90 structure began to break down, increasing the ability to deliver cancer-targeted anti-cancer drugs due to structural collapse when using nano-ZIF-90 as a drug carrier.

Source: Vietnam Journal of Catalysis and Adsorption

DOI: 10.62239/jca.2025.052

Authors: Ta Ngoc Thien Huy, Duong Le, Vy Tran, Duong Le, Bui Ha, Trinh Bai, Linh Nguyen, Phuong Nguyen, Don Ta

Institutions: Kien Giang University, Nha Trang University, Hanoi University of Science and Technology, Hanoi University of Pharmacy, Hanoi University of Mining and Geology

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415043439

FWCI:

Cites:

Cited by:

Related to: