Phytochemical Study of Ethanol Extract of Sengkubak Leaves (Pycnarrhena cauliflora (Miers) Diels) and Molecular Docking Analysis as a Potential Anti-Breast Cancer Agents
Year: 2025
Type: article
Abstract: Reactive Oxygen Species (ROS) are a group of free radicals that play a major role in causing oxidative stress, which can trigger the development of degenerative diseases such as cancer. Sengkubak (Pycnarrhena cauliflora (Miers) Diels) contains antioxidant that may help protect the body from free radical exposure. This study aims to identify the metabolite compounds present in Sengkubak leaves through GC-MS analysis and to evaluate their anticancer potential of its major metabolites through in silico molecular docking analysis. The leaf simplicia was extracted using the maceration method with ethanol as the solvent. The analyses performed included GC-MS analysis and molecular docking analysis of the major compounds identified by GC-MS to evaluate their anticancer potential. GC-MS analysis identified a total of 84 compounds, with the five major ones being Phytol, Farnesol isomer a, L-Gala-L-ido-octose, E-11-HexadecenoicAacid ethyl ester, and Pentadecanoic acid ethyl ester. Furthermore, molecular docking analysis of the five major compounds demonstrated potential anticancer activity against breast cancer targets.
Authors: Universitas Palangka Raya, Indonesia, Yuneta Yuneta, Wahyu Nugroho, Septaria Yolan Kalalinggi, Erwin Prasetya Toepak
Institution: University of Palangka Raya
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4415043693
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