Diagnostic Accuracy of Diffusion-weighted Magnetic Resonance Imaging in Detecting Deep Myometrial Invasion by Endometrial Tumor Taking Histopathology as Gold Standard
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To evaluate the diagnostic accuracy of DW-MRI in detecting deep myometrial invasion in endometrial carcinoma, using histopathology as the reference standard. Methods: This cross-sectional validation study was conducted at the Department of Radiology, Hayatabad Medical Complex, Peshawar, from January to June 2023. A total of 124 women (aged 30–70 years) with biopsy-proven endometrial carcinoma scheduled for hysterectomy were enrolled. DW-MRI findings were interpreted by an experienced radiologist and compared with postoperative histopathological results. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated. Results: DW-MRI demonstrated a sensitivity of 81.5% (95% CI: 72.1–88.9%) and a specificity of 87.5% (95% CI: 71.0–96.5%) in detecting deep myometrial invasion. The positive predictive value was 94.9%, and the negative predictive value was 62.2%, with an overall diagnostic accuracy of 83.1%. Performance was superior in postmenopausal women and low-grade tumors. Conclusion: DW-MRI exhibits high diagnostic accuracy in assessing deep myometrial invasion in endometrial carcinoma, supporting its role as a reliable preoperative imaging modality. Its non-invasive nature and high reproducibility make it a valuable tool in clinical practice.
Authors: Adnan Sajid, Ghazala Wahid, Ayesha Jawaid, Naila Tamkeen, Saima Rehman, Gul E Lala Noman
Institution: Hayatabad Medical Complex
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415055643