Work

Systemic Disease Associations of Oral Lichenoid Disease: A Retrospective Case–Control Study

Year: 2025

Type: article

Abstract: OBJECTIVE: To analyze the association between oral lichen planus (OLP), oral lichenoid lesions (OLL), and other comorbidities. MATERIAL AND METHODS: A case-control study of 205 OLP, 96 OLL patients, and 301 age- and sex-matched controls from Kuopio University Hospital was performed. Medical history, regular medications, allergies, lichen planus in the body, and clinical features of OLP/OLL were recorded. RESULTS: The prevalence of autoimmune hypothyroidism (HT) was 12.2% in OLP, 18.8% in OLL, and 9% in the control group; the estimated odds ratio (OR) was 1.425 (95% confidence interval [CI] 0.793 to 2.562) (p = 0.237) for OLP and 2.292 [95% CI 1.175-4.47] (p = 0.015) for OLL. Allergies were found in 36.1% of OLP patients and in 22.9% of controls; the estimated OR was 1.872 [95% CI 1.245-2.815] (p = 0.003) for OLP. Patients with HT had more often erosive lesions than patients without HT. CONCLUSION: The present study suggests that OLL is associated with HT. The association between OLP and HT was not statistically significant. Allergies are associated with OLP.

Source: Oral Diseases

DOI: 10.1111/odi.70117

Authors: Mari Vehviläinen, Tuomas Selander, Tuula Salo, Maria Siponen

Institutions: University of Helsinki, Kuopio University Hospital, Oulu University Hospital, University of Oulu, University of Eastern Finland

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,990