Year: 2025
Type: article
Abstract: Saliva,often termed the mirror of the body, is increasingly recognized for its diagnostic potential in oral and systemic diseases. With advancements in proteomics, genomics, and metabolomics, salivary biomarkers offer a non-invasive, cost-effective, and patient-friendly means to support diagnosis, prognosis, and monitoring across many dental disciplines. Prosthodontics particularly benefits from this because prosthetic rehabilitation impacts and is impacted by systemic health, mucosal status, and oral micro environment. This review examines the biochemical basis of salivary diagnostics,categories of relevant biomarkers,and their specific applications in prosthodontic care covering edentulism,ridge resorption,implant health, xerostomia, oral cancer surveillance,and prosthesis related complications.Technological advances, limitations, and future directions for integrating chairside salivary diagnostics into personalized prosthodontics are also discussedThe evidence underscores salivary biomarkers promise in enhancing patient-centered outcomes and shaping the future of biomarker-guided prosthetic therapy.
Authors: Rohit Raghavan, Shajahan P.A, Shaman Shalu S B
Institution: Royal Dental College
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415064198
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