Work

Breast Findings in Females With Beckwith–Wiedemann Syndrome

Year: 2025

Type: article

Abstract: Beckwith-Wiedemann syndrome (BWS) is an overgrowth condition caused by epigenetic defects on chromosome 11p15. Children with BWS have a predisposition to embryonal tumors such as Wilms tumor and hepatoblastoma. However, few reports of breast tumors in females with BWS have been published and the risk of malignancy and need for screening remains unknown. In this report, we describe six adolescent or adult females with BWS who developed benign or malignant breast tumors. Additionally, we conducted a review of the literature to compare our findings with previously reported cases.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.32109

Authors: Liron D. Grossmann, Andrew M. George, Tom Lapidus, Cassandra Ligh, Suzanne P. MacFarland, Jennifer M. Kalish

Institutions: Children's Hospital of Philadelphia, Sheba Medical Center, Edmond and Lily Safra Children's Hospital, University of Pennsylvania

Language: English

Topic: Genetic Syndromes and Imprinting

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,640