Work

Underreporting of molecular targets in surgically treated patients with peritoneal metastasis of gastric cancer

Year: 2025

Type: article

Abstract: The management of gastric cancer (GC) with peritoneal metastasis (PM) remains a significant clinical challenge. Despite advances in molecular profiling, the underreporting of key molecular markers in patients undergoing surgical treatment for GC with PM is concerning. Signet ring cell (SRC) histology is associated with poor prognosis and chemoresistance, while Laurén diffuse subtype is linked to a higher risk for PM. Despite the established role of HER2 in GC progression, its impact on the efficacy of surgical treatment is not clearly defined. The lack of comprehensive reporting on these and recent molecular markers underscores the need for further research. Incorporating molecular diagnostic into clinical practice could improve the personalisation of treatment for GC with PM and overcoming important drug resistance issues, enhancing the effectiveness of current therapy approaches.

Source: European Journal of Surgical Oncology

DOI: 10.1016/j.ejso.2025.110502

Authors: A. Castagna, A. Ramouz, I. Trinidad-Gutiérrez, N. Brindl, A. Brandl

Institutions: University Hospital Heidelberg, Hospital Universitario Reina Sofía, Heidelberg University

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,810