Epidemiology of non-central line-associated primary bloodstream infections in a network of Indian hospitals: A prospective surveillance study over 7 years (2017-2024)
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To estimate the profile of non-central line-associated primary bloodstream infections (non-CLABSIs) in intensive care units of Indian hospitals participating in the standardized health-care-associated infection surveillance program. METHODS: This is a multicentric, network-based, prospective surveillance study conducted in 180 individual intensive care units of 47 Indian tertiary care hospitals that were part of the Health-Care-Associated Infection Surveillance Network between May 2017 and April 2024. The non-CLABSIs were defined, monitored, and observed using standardized definitions and surveillance protocols (www.haisindia.com). RESULTS: A total of 7092 laboratory-confirmed non-CLABSI cases and 30,74,954 patient days from 2017 to 2024 were recorded. The overall pooled non-CLABSI rate was 2.3 per 1000 patient days. Gram-negative isolates were the most predominant (5240/7659; 68.4%), including Klebsiella spp. (1766/5240; 33.7%), Acinetobacter baumannii (1613/5240; 30.8%), and Escherichia coli (582/5240; 11.1%). Gram-positive isolates (1728/7659; 22.6%) predominantly included Staphylococcus aureus (953/1728; 55.1%) and Enterococcus spp. (747/1728; 43.2%). Carbapenem resistance was common in Gram-negative infections, particularly in A. baumannii (1253/1554; 80.6%) and Klebsiella spp. (1209/1697; 71.2%). Among Gram-positive, S. aureus exhibited a high level of resistance to methicillin (529/748; 70.7%). CONCLUSIONS: This surveillance study underscores the need to expand infection prevention and control strategies to include non-device-associated risk factors. This will lead to the formulation of comprehensive infection prevention and control programs, mitigating the burden and clinical outcomes of non-CLABSI.
Authors: Ashish Kumar Srivastava, Arpan Kumar Thakur, Kumari Vandana Singh, Rasna Parveen, Mamta Puraswani, Parul Singh, Arunaloke Chakrabarti, Camilla Rodrigues, Pallab Ray, Manisha Biswal, Neelam Taneja, Shivaprakash M. Rudramurthy, Archana Angrup, Inderpaul Sehgal, Ritesh Agarwal, Chand Wattal, Vimala Venkatesh, Nandini Sethuraman, Sanjay Bhattacharya, Vijaya Lakshmi Nag, Vibhor Tak, Bijayini Behera, Vinaykumar Hallur, Veeraragavan Balaji, Raja Ray, Sanjeev K. Singh, Chiranjay Mukhopadhyay, Joy Sarojini Michael, Bashir Ahmad Fomda, Tadepalli Karuna, Vijayshri Deotale, Amber Prasad, Tapan Majumder, Puneet Kumar Gupta, Kanne Padmaja, Vijeta Bajpai, Jyoti Iravane, Reema Nath, Renu Gur, Nari M. Lyngdoh, Clarissa Lyngdoh, Sheela Devi, Shalini Malhotra, Rajni Gaind, Ranjana Devi Khuraijam, Rajni Sharma, Summaiya Mullan, John Antony Jude Prakash, Shaoli Basu, Hema Paul, Priscilla Rupali, Sheetal Verma, M.A. Thirunarayan, Hirak Jyoti Raj, Rushika Saxena, Sangita Rajdev, Neeraj Goel, Sudipta Mukherjee, Yamunadevi V. Ramanathan, Juliah Chelliah, Satyam Mukherjee, Aparna Sonowal, Sharmila Sen Gupta, Prachi Verma, Jayashree Muralidharan, Lakshmi Narayana Yaddanapudi, Ajay Duseja, Kajal Jain, Usha Dutta, Parthasarathi Bhattacharyya, Ashoka Mahapatra, Tapas Kumar Som, Rashmi Ranjan Das, Swagata Tripathy, Tushar Mishra, Anupam Dey, Vandana KE, Muralidhar Varma, Balram Ji Omar, Ankit Aggarwal, Sherish Baqal, Langpoklakpam Chaoba Singh, Neeraj Gupta, Pradeep Kumar Bhatia, Kuldeep Singh, Daisy Khera, D. Himanshu, Sarika Gupta, Zia Arshad, Ullash Bhabor, Rahul Sarode, Satyajit Pradhan, Sivanantham Krishnamoorthi, Shalini Dewan Duggal, Rajender Kumar, G.P. Kaushal, Vikas Dabas, Subodh Kumar, Kapil Dev Soni, Sushma Sagar, Richa Aggarwal, Gyaninder Pal Singh, Ashish Bindra, Kamran Farooque, Kamini Walia, Purva Mathur
Institutions: All India Institute of Medical Sciences, All India Institute of Medical Sciences Jodhpur, Post Graduate Institute of Medical Education and Research, P. D. Hinduja Hospital and Medical Research Centre, Sir Ganga Ram Hospital, King George's Medical University, Apollo Hospitals, Tata Medical Center, All India Institute of Medical Sciences Bhubaneswar, Christian Medical College, Vellore, Institute of Post Graduate Medical Education and Research, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kasturba Medical College, Manipal, Sher-i-Kashmir Institute of Medical Sciences, All India Institute of Medical Sciences Bhopal, Mahatma Gandhi Institute of Medical Sciences, All India Institute of Medical Sciences Rishikesh, Agartala Government Medical College, Nizam's Institute of Medical Sciences, Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Government Medical College, Assam Medical College, Dr Baba Saheb Ambedkar Hospital, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Pondicherry Institute of Medical Sciences, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Safdarjang Hospital, Vardhman Mahavir Medical College & Safdarjung Hospital, Regional Institute of Medical Sciences, SMS Medical College, Government Medical College, Kasturba Medical College Hospital, Indian Council of Medical Research
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
Award: G2148135188
OpenAlex ID: W4415093140