Work

Mapping a reproducible water fraction and T 1 using MP2RAGE and variable flip angle quantitative MRI protocols

Year: 2025

Type: article

Abstract: PURPOSE: Water fraction (WF) estimation, a form of quantitative MRI mapping, is typically performed using the variable flip angle (VFA) approach. In this study, WF estimation was extended to include the magnetization prepared with 2 rapid gradient echoes (MP2RAGE) protocol. The two methods were compared to assess the consistency of WF values across both acquisition strategies. METHODS: maps were calculated using both the VFA and MP2RAGE acquisition protocols. In vivo and phantom datasets were used to assess the comparability of WF estimation between the two methods. Repeatability and reproducibility were evaluated both within each acquisition approach and across the two protocols. RESULTS: maps derived from the VFA and MP2RAGE approaches. The extraction of WF maps from the MP2RAGE protocol was validated, and the consistency of WF estimation across both methods was confirmed. CONCLUSION: maps derived from both the VFA and MP2RAGE methods. The ability to obtain reliable WF estimates from either protocol expands the applicability of WF mapping across a broader range of imaging studies.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.70096

Authors: Eden Mama, Rona Shaharabani, José P. Marques, Aviv A. Mezer

Institutions: Hebrew University of Jerusalem, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,680