Work

Lanostane–Meroterpene Conjugates with Unusual Aryl Ether Linkage and a Lanostane Dimer from Artificially Cultivated Fruiting Bodies of Ganoderma cf. hochiminhense

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Ten previously undescribed compounds, including eight lanostane–meroterpene conjugates, ganohochimins A–H ( 1 – 8 ), a lanostane dimer, ganohochimate A ( 9 ), and a meroterpenoid, fornicin F ( 10 ), were isolated from the cultivated mushroom Ganoderma cf. hochiminhense (strain TBRC-BCC 22084). The 24 S -configuration of ganohochimin A ( 1 ) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A ( 9 ) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC 50 7.7–33 μM) and noncancerous Vero cells (IC 50 6.3–30 μM).

Source: ACS Omega

DOI: 10.1021/acsomega.5c06826