Effect of Ocimum basilicum Herbs Extract on Pro-Inflammatory Cytokines in Ethanol-Induced Liver Damage in Rats
Year: 2025
Type: article
Abstract: OBJECTIVE: Aim: The aim of this study is to evaluate the hepatoprotective and immunomodulatory effects of Ocimum basilicum extract on pro-inflammatory cytokines, specifically TNF-α, IL-6, and IL-1β, in a rat model of ethanol-induced liver damage. PATIENTS AND METHODS: Materials and Methods: A total of 120 male rats were divided into four groups: a control group, an ethanol-induced liver damage group, a low-dose basil treatment group, and a high-dose basil treatment group. Pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) were measured using ELISA. RESULTS: Results: The ethanol exposure group showed significantly elevated TNF-α (548.8 ± 83.78 pg/mL), IL-6 (410.3 ± 167.7 pg/mL), and IL-1β (373.1 ± 127.7 pg/ mL) compared to the control group. Basil supplementation, particularly at high doses (100 mg/kg), effectively reduced these cytokines, with TNF-α (316.4 ± 57.37 pg/mL) and IL-6 (133.9 ± 86.76 pg/mL) levels approaching control values. IL-1β was also significantly reduced (152.3 ± 79.37 pg/mL) but remained slightly elevated. CONCLUSION: Conclusions: This study showed that Ocimum basilicum extract has potent hepato protective and anti-inflammatory properties, making it a promising natural therapeutic agent for alcohol-induced liver damage.
Source: Wiadomości Lekarskie
DOI: 10.36740/wlek/208443
Authors: Hussein Talib Abdullah, Almas M. Al-Bayati, Abbas Najm Aldin Saleh, Karima Akool AlSalihi, Hayder H. Abed
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4415104076