Work

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Year: 2025

Type: article

Abstract: ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.

Source: Nature Communications

DOI: 10.1038/s41467-025-64128-0

Authors: Dong Wang, Fan Bu, Ge Yang, Bin Liu

Institution: University of Minnesota

Language: English

Topic: Virology and Viral Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990