Work

Efflux Pump Inhibitors and their Role in Combating Bacterial Drug Resistance

Year: 2025

Type: article

Abstract: ABSTRACT: The use of efflux pump inhibitors (EPIs) as adjuvant therapy to combat bacterial resistance to several antibiotics has been a proven method to fight antimicrobial resistance. Antibiotic- expelling efflux pumps, which are found in bacterial cell membranes, play a major role in the development of multidrug resistance. Therefore, EPIs, which are meant to inhibit these pumps, have the potential to make the current antibiotic arsenal more effective. Here we classify efflux pumps, analyse the many complexities of EPI processes, and emphasize the range of sources and applications. This academic review thus highlights the functioning of efflux pumps, the critical role that efflux pump inhibitors play and advocates for more research into efflux pump inhibitors.

Source: Biosciences Biotechnology Research Asia

DOI: 10.13005/bbra/3414

Authors: Benjamin Isaac Thomson, Shainaba A Saadhali

Institutions: SRM Institute of Science and Technology, National Institute of Research in Tuberculosis

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415118357