Work

Tribological effects of hyaluronic acid concentration on articular cartilage: pin-on-plate friction tests in porcine and osteoarthritic human tissue

Year: 2025

Type: article

Abstract: Hyaluronic acid (HA) is the main biopolymer used in intra-articular injections for osteoarthritis (OA).HA is usually applied at 1-3 mg/mL, though the optimal level remains unclear.The purpose of this study was to determine the effect of HA concentration on the friction in osteoarthrosis.Samples from the osteoarthritic head of a human femur and porcine controls were tested in a pin-on-plate setup.The results showed a statistically significant effect of HA concentration on the friction in a group of porcine cartilage.In a group of osteoarthritic cartilage, such a relationship did not occur.This comparison highlights that degeneration limits HA's effect.

Source: Journal of Theoretical and Applied Mechanics/Mechanika Teoretyczna i Stosowana

DOI: 10.15632/jtam-pl/210752

Authors: Adam J. Mazurkiewicz, Celina Pezowicz, Anna Nikodem, Maciej Przybyłek, Dominika Mazurkiewicz

Institutions: Bydgoszcz University of Science and Technology, Wrocław University of Science and Technology, Nicolaus Copernicus University, Gdańsk Medical University

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Politechnika Wrocławska