Year: 2025
Type: article
Abstract: = 5 weeks). While PL-treated defects exhibited reduced contraction and improved macroscopic appearance over Mfx alone, micro-CT and mechanical testing revealed no significant differences in subchondral bone remodeling or repair tissue stiffness. Histological analysis and grading showed no significant improvements in cartilage repair quality across treatment groups, suggesting that while PL may influence early clot stability, its effects on long-term tissue maturation remain uncertain. "Future studies are needed to determine whether PL-based augmentation provides sustained functional benefits, potentially in combination with additional biological or mechanical strategies".
Source: Biomaterials Science
DOI: 10.1039/d5bm00372e
Authors: Hanna Solomon, Julie Gordon, Maddie Hasson, Hannah Arnade, Jordan Parker, Beatriz Dias, Amogh Magesh, William X. Patton, John F. Peroni, Jay M. Patel
Institutions: Emory University, Atlanta VA Medical Center, University of Georgia
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G196810821, G687203789, G9000046174
OpenAlex ID: W4415126340