Analysis of Nonlinear Vibrational Dynamics of Moving Structures - Part B: Multiscale Modeling of Blood-Plate Interactions in Microfluidic Systems
Year: 2025
Type: preprint
Abstract: The study of blood flow in microscopic environments has garnered significant interest in the fields of biophysics and biomedical engineering. This article investigates the nonlinear vibratory dynamics of blood-plate interactions within microfluidic systems, employing a multiscale analysis approach. The research is driven by the urgent need to decode the intricate dynamics underpinning the interactions between microscale structures and biological fluids, particularly blood, with the aim of advancing our understanding of their fundamental principles and extensive implications. This urgency is fueled by the revolutionary potential of the miniaturization of fluid manipulation within microfluidic systems, which enables meticulous control over physiological conditions, fosters high-throughput experimentation, and facilitates seamless integration with other microfluidic and lab-on-a-chip technologies, propelling the field forward. central to this study is the development of a semi-analytical model that furnishes detailed insights into the vibratory patterns exhibited by microscopic circular plates immersed in blood. This model yields a precise depiction of the dynamics involved, elucidating the indispensable role of fluid-structure interactions in shaping the mechanical responses of these microstructures within physiological contexts. Moreover, the research highlights the deployment of advanced Computational Fluid Dynamics (CFD) techniques to conduct a comparative scrutiny of the intricate interactions between blood and microscale structures. This methodology facilitates a comprehensive exploration of the underlying mechanisms and their ramifications, promising heightened insights into the dynamics under consideration. Through a synthesis of theoretical modeling and computational simulations, this study endeavors to unravel the complex dynamics governing blood-plate interactions within microfluidic systems. Initial findings from this comparative analysis notably underscore the profound impact of blood interactions on the vibrational characteristics of the plates, significantly influencing their modes and frequencies. This highlights the imperative of integrating insights from fluid-structure interactions into the conceptualization and design phases of these microstructures for their effective utilization in biomedical fields. Moreover, the juxtaposition between semi-analytical techniques and CFD simulations not only validates the effectiveness of the semi-analytical model but also unveils opportunities for its further refinement and exploration. In conclusion, this study has unveiled the intricate dynamics of blood-plate interactions within microfluidic systems, highlighting the pivotal influence of fluid-structure interactions on mechanical responses. By emphasizing the critical role of understanding these interactions, the research sets the stage for future advancements through the ongoing refinement of the semi-analytical model. These insights not only enrich our comprehension of fluid-structure interactions but also offer potential for improving biomedical devices and advancing therapeutic strategies.
Authors: Hafida Chekkouchi, El Bekkaye Merrimi
Institution: Mohammed V University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4415143409
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