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When protection becomes a paradox: maternal antibodies clear oral rotavirus vaccines before the infant immune system can learn

Year: 2025

Type: article

Abstract: Child morbidity and mortality from infectious diseases remain high in many low- and middle-income countries, highlighting the need for the development of more effective vaccination strategies. In this issue of The EMBO Journal, Chandler et al, demonstrate in a neonatal mouse model that maternal antibodies interfere with oral rotavirus vaccination by accelerating viral clearance, offering a mechanistic rationale for reduced vaccine performance in high-burden settings.

Source: The EMBO Journal

DOI: 10.1038/s44318-025-00583-1

Authors: Ashomathi Mollin, Stephanie N Langel

Institution: Case Western Reserve University

Language: English

Topic: Viral gastroenteritis research and epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $7,990