Year: 2025
Type: review
Abstract: Mammals have evolved under an inseparable association with diverse microbial gut colonizers; thus, fine-tuned host-microbial interactions shape our susceptibility to immunological, oncogenic, metabolic and infectious outcomes. The past two decades have seen a rapid expansion of research into intestinal bacterial communities that impact host health in many preclinical and clinical settings. Meanwhile, other less abundant microorganism domains, including fungi, remain far less explored. This Review provides an overview of the literature on the gut mycobiome and evidence of its contributions to host physiology and disease over the past two decades in experimental rodent models, which have been foundational to our current understanding of host-microbe interactions.
Source: Lab Animal
Institution: University of Wisconsin–Madison
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,390
Awards: G3225289916, G3707728881, G6845496622, G6870083318, Exploring the role, regulation, and antimicrobial function of Paneth cell peptides PYY and NPY in maintaining gut microbial commensalism and innate immune defense, Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk., Metabolism and Nutrition Training Program, Role of microbially-derived metabolites in anti-tumor immunity in breast cancer
OpenAlex ID: W4415143510