Therapeutic effect of Anethum graveolens L. (Dill) seed extract for the treatment of dextran sodium sulfate (DSS) induced ulcerative colitis in Wistar rats
Year: 2023
Type: article
Abstract: The purpose of this study was to determine whether the Anethum graveolens L. seed (AGS) extract has any anti-oxidant, anti-inflammatory, or immune-modulatory activities against Ulcerative colitis (UC). AGS extract has found widespread use in folk medicine. Twenty seven (n=27) adult female Wistar albino rats were employed for the experiment involving Dextran Sodium Sulfate (DSS) induced UC. These rats were distributed randomly into five groups, each consisting of six animals (n=6), with the exception of group 1, which had three animals (n=3). Group 1 received 0.5% Carboxy methyl cellulose (CMC) (p.o.), Group 2 received 5% DSS (p.o.), Group 3 received 350 mg/kg b.w. mesalazine (p.o.), and Groups 4, 5, respectively, received 200 and 400 mg/kg AGS extract (p.o). Along with administering DSS, the treatment lasted for 12 days. In comparison to the DSS-treated group, groups 4, and 5, there was a considerable weight gain. Comparing groups 4 and 5 to group 2, the groups 4 and 5 showed a substantial decrease in Disease Activity Index (DAI), colon damage (p
Source: DergiPark (Istanbul University)
Authors: Rajendran, Karthick Kannan, Indumathy, Indumathy
Institution: Madras Medical College
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4415144418